| Type | MGI:General | Description | >50% of sperm exhibit severely malformed nuclei mild defects include blunt nuclear tips and concave indentations at the base of the sperm nucleus spermatids undergoing elongation and condensation show a lack of coherence between the inner and outer nuclear membranes and fail to generate a continuous nuclear dense lamina in the subacrosomal region other defects include abnormal invaginations of the nuclear envelope into the nuclear lumen, separation and bulging of the outer or inner membrane of the nuclear envelope, and detachment of the chromatin from the inner nuclear membrane the nuclear lamina appears stretched and appears to form abnormal gaps esp. in regions that are most likely exposed to increased physical forces during nuclear shaping abnormal nuclear envelope stretching and chromatin detachment is also noted in round spermatids at earlier steps, prior to the formation of manchette and acroplaxome |
