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Comment :

Type  MGI:General Description  starting at 2 months of age, estrogen-free homozygotes exhibit spontaneous microvesicular hepatic steatosis of liver cells in zones 3 and 2 (centrilobular and intermediate zones in the lobules) while liver cells in zone 1 (periportal) remain intact mutant liver cells with microvesicular steatosis are devoid of large fat droplets; however, the cytoplasm of some liver cells filled with numerous fat droplets contain both small and large fat droplets administration of 17beta-estradiol rescues homozygotes from massive hepatic steatosis