| Type | MGI:General | Description | ex vivo, calvaria-derived cultures containing osteoblast precursors and/or immature osteoblasts of newborn homozygotes show a significant increase in the number of alkaline-phosphate (ALP)-positive cells, suggesting that osteoblast differentiation is enhanced upon exposure to rhBMP2, the ALP activity of mutant calvaria-derived cells is significantly increased relative to similarly-derived wild-type cells although ALP activity remains at background levels by day 7 of culture at at low concentrations of rhBMP2, it is significantly increased by week 3 of culture even without exogenous BMP2 |
