| Type | MGI:General | Description | mice develop multiple polyps in the small intestine one month after completion of pIpC injection to induce Cre expression polyps show a large excess of crypt-like units at their base and aberrant positioning of crypts along the edges of villi overgrowth and insertions of stromal cells from the base of the polypoid mass are seen in the small intestine one month after completion of pIpC injection to induce Cre expression intestinal stem cells exhibit increased proliferation due to Akt activation and nuclear localization of beta-catenin resulting in an increase of intestinal stem cells in the crypts these excess stem cells initiate de novo crypt formation and crypt fission at a higher rate than in controls |
