| First Author | Weinstein JS | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 10 | Pages | 1197-1205 |
| PubMed ID | 27573866 | Mgi Jnum | J:259953 |
| Mgi Id | MGI:6141679 | Doi | 10.1038/ni.3554 |
| Citation | Weinstein JS, et al. (2016) TFH cells progressively differentiate to regulate the germinal center response. Nat Immunol 17(10):1197-1205 |
| abstractText | Germinal center (GC) B cells undergo affinity selection, which depends on interactions with CD4(+) follicular helper T cells (TFH cells). We found that TFH cells progressed through transcriptionally and functionally distinct stages and provided differential signals for GC regulation. They initially localized proximally to mutating B cells, secreted interleukin 21 (IL-21), induced expression of the transcription factor Bcl-6 and selected high-affinity B cell clones. As the GC response evolved, TFH cells extinguished IL-21 production and switched to IL-4 production, showed robust expression of the co-stimulatory molecule CD40L, and promoted the development of antibody-secreting B cells via upregulation of the transcription factor Blimp-1. Thus, TFH cells in the B cell follicle progressively differentiate through stages of localization, cytokine production and surface ligand expression to ''fine tune'' the GC reaction. |
