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Publication : Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses.

First Author  Takahashi S Year  1995
Journal  FEBS Lett Volume  368
Issue  3 Pages  455-60
PubMed ID  7635198 Mgi Jnum  J:30470
Mgi Id  MGI:77980 Doi  10.1016/0014-5793(95)00713-j
Citation  Takahashi S, et al. (1995) Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses. FEBS Lett 368(3):455-60
abstractText  Through screening of a murine brain cDNA library, we have isolated two brain specific cDNAs encoding highly homologous proteins, named 921-L and 921-S, comprised of 134 amino acids with 80% identity. Immunohistological study with the mAbs raised against the bacterially expressed 921 proteins showed that 921-L protein is distributed at the dendritic region and 921-S at the neuronal somatic surface. Immuno-electron microscopic study revealed that both 921 proteins are localized at the presynaptic terminal, indicating that the 921 proteins are differentially expressed at the dendritic and somatic presynapses.
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