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Publication : New members of the chemokine receptor gene family.

First Author  Raport CJ Year  1996
Journal  J Leukoc Biol Volume  59
Issue  1 Pages  18-23
PubMed ID  8558062 Mgi Jnum  J:30897
Mgi Id  MGI:79184 Doi  10.1002/jlb.59.1.18
Citation  Raport CJ, et al. (1996) New members of the chemokine receptor gene family. J Leukoc Biol 59(1):18-23
abstractText  Chemokines are relatively small peptides with potent chemoattractant and activation activities for leukocytes. Several chemokine receptors have been cloned and characterized and all are members of the G protein-coupled receptor superfamily. Using degenerate oligonucleotides and polymerase chain reaction, we have identified seven novel receptors. Two of these sequences are presented here for the first time. We have shown, with gene mapping studies, that receptors with the highest sequence similarity are closely linked on human chromosomes. This close genetic association suggests a functional relationship as well.
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