| Primary Identifier | MGI:97887 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 19684 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein domain specific binding activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of G1/S transition of mitotic cell cycle; and regulation of postsynaptic neurotransmitter receptor diffusion trapping. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; ruffle; and stereocilium base. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). PHENOTYPE: Mice homozygous for a targeted mutation display mild degenerative changes in the liver and hyperbilirubinemia. Adult homozygotes exhibit profound deafness, but not imbalance, associated with progressive degeneration of stereocilia of cochlear hair cells after the onset of hearing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
