| First Author | Uekawa N | Year | 2004 |
| Journal | FEBS Lett | Volume | 575 |
| Issue | 1-3 | Pages | 30-4 |
| PubMed ID | 15388329 | Mgi Jnum | J:92822 |
| Mgi Id | MGI:3054581 | Doi | 10.1016/j.febslet.2004.08.033 |
| Citation | Uekawa N, et al. (2004) Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts. FEBS Lett 575(1-3):30-4 |
| abstractText | Senescence of mammalian cultured cells is essentially organized by a machinery of cell division and cellular stresses induced by various extracellular stimuli. Here, we show that in mouse embryonic fibroblasts (MEFs) culture in vitro, expression of an inflammatory cytokine, interleukin-1beta (IL-1beta) and its antagonist, IL-1 receptor antagonist (IL-1Ra) are induced by senescence. The kinetics of IL-1beta-expression was similar to that of p38 activation during MEFs culture. We also found a distinguishable accelerated senescence in cell growth in IL-1Ra deficient MEFs culture. Our results suggest that IL-1beta signaling pathway is involved in activation of p38 linked cellular senescence. |
