| Primary Identifier | IPR008030 | Type | Domain |
| Short Name | NmrA-like |
| description | NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA []. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. It lacks most of the active site residues of the SDR (short-chain dehydrogenases/reductases) family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG [].This domain can also be found in other atypical SDRs, such as HSCARG (an NADPH sensor) []and PCBER (phenylcoumaran benzylic ether reductase) []. |
