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Comment :

Type  MGI:General Description  the uterus was completely nonreceptive to blastocyst implantation as a result of impaired progesterone (P4) functions, including a 2-fold reduction in P4 binding to the nuclear progesterone receptor (PR), a fractional reduction in the number of P4 binding sites, attenuated PR transcriptional activity, and down-regulation of several P4-regulated genes in the uterus