| Primary Identifier | IPR029755 | Type | Family |
| Short Name | IRE-BP2 |
| description | In mammals, iron regulatory proteins (IRPs) 1 and 2 posttranscriptionally regulate expression of genes involved in iron metabolism by binding mRNA motifs called iron responsive elements (IREs) []. IRP1 is a bifunctional protein that also has aconitase activity. IRP1 mostly exists in a non-IRE-binding, [4Fe-4S]cluster aconitase form which predominates when iron levels are normal; but if levels drop sufficiently the disassembly of the [4Fe-4S]-cluster occurs and there is a change of conformation to the IRE-binding form. On the other hand, IRP2 does not assemble an Fe-S cluster, lacks aconitase activity, and spontaneously binds IREs []. Since IRP1 is predominantly in the enzymatic cytoplasmic aconitase form, it is IRP2 that acts as the major metabolic regulator that maintains iron homeostasis []. IRP2 is also regulated. An iron-regulated E3 ubiquitin ligase complex targets IRP2 for proteasomal degradation [, ].This entry represents iron regulatory protein 2, also known as iron-responsive element-binding protein 2 (IRE-BP2). |
