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Allele : Snca<tm1.1Koks> synuclein, alpha; targeted mutation 1.1, Sulev Koks

Primary Identifier  MGI:5517595 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Snca
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 2 was replaced with a modified one in which a point mutation results in the amino acid substitution of proline for alanine at position 30 (A30P), mimicking a mutation found in some Parkinson's disease patients. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted between exon 1a and exon 1b.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • SNCA A30P,
  • SNCA A30P
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

6 Publication categories

Trail: Allele