Primary Identifier | MGI:5517595 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Snca |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 2 was replaced with a modified one in which a point mutation results in the amino acid substitution of proline for alanine at position 30 (A30P), mimicking a mutation found in some Parkinson's disease patients. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted between exon 1a and exon 1b. |