Primary Identifier | MGI:2178809 | Allele Type | Targeted |
Attribute String | Null/knockout, Reporter | Gene | Sox18 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The gene was disrupted by replacing sequences encoding the HMG box with a LoxP-neo-LacZ cassette via homologous recombination. RT-PCR analysis of mutant embryos confirmed transcripts of the HMG coding region were absent although transcripts of the trans-activating domain downstream of the LoxP-neo-LacZ cassette were present. |