| Primary Identifier | MGI:104963 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 18166 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Acts upstream of or within several processes, including glucose metabolic process; neuropeptide signaling pathway; and sensory perception of pain. Predicted to be located in axon and synaptic vesicle. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; immune system; and liver. Used to study obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1). PHENOTYPE: Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
