| Primary Identifier | IPR007048 | Type | Domain |
| Short Name | IraD/Gp25-like |
| description | This domain is found in baseplate protein Gp25 from phage T4 and related phages, and Gp25-like proteins from bacteria [, ]. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerisation, playing a critical role in sheath assembly and contraction [, ]. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD) []. This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems. |
