| First Author | Yan Y | Year | 2006 |
| Journal | Neoplasia | Volume | 8 |
| Issue | 1 | Pages | 52-8 |
| PubMed ID | 16533426 | Mgi Jnum | J:110187 |
| Mgi Id | MGI:3639557 | Doi | 10.1593/neo.05652 |
| Citation | Yan Y, et al. (2006) Efficacy of Polyphenon E, Red Ginseng, and Rapamycin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice. Neoplasia 8(1):52-8 |
| abstractText | The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene for their ability to inhibit pulmonary adenoma formation and growth. We found that treatment with polyphenon E exhibited a significant reduction on both tumor multiplicity and tumor load (tumor multiplicity x tumor volume) in a dose-dependent fashion. Polyphenon E (2% wt/wt) in the diet reduced tumor multiplicity by 46% and tumor load by 94%. This result provided key evidence in support of a phase II clinical chemoprevention trial of lung cancer. Administration of red ginseng in drinking water decreased tumor multiplicity by 36% and tumor load by 70%. The mammalian target of rapamycin inhibitor rapamycin showed significant efficacy against lung tumor growth in the tumor progression protocol and reduced tumor load by 84%. The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice. |
