| Primary Identifier | IPR026810 | Type | Family |
| Short Name | Tshz3 |
| description | Teashirt 3 is a transcriptional regulator involved in developmental processes []. It has function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. It associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). It regulates the development of neurons involved in both respiratory rhythm and airflow control []. It promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. It is involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes []. It is involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter []. |
