| Primary Identifier | MGI:1196287 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13368 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA binding activity and nuclease activity. Predicted to be involved in apoptotic DNA fragmentation; apoptotic chromosome condensation; and negative regulation of apoptotic DNA fragmentation. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of chromatin. Orthologous to human DFFB (DNA fragmentation factor subunit beta). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and developmentally normal; however, mutant thymocytes and other cell types fail to undergo apoptotic DNA fragmentation in response to dexamethasone or other apoptotic stimuli. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
