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Protein Coding Gene : Ubqln1 ubiquilin 1
Primary Identifier  MGI:1860276 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  56085
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable several functions, including identical protein binding activity; kinase binding activity; and polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of toll-like receptor 3 signaling pathway. Located in autophagosome. Is expressed in liver. Orthologous to human UBQLN1 (ubiquilin 1).
PHENOTYPE: Homozygous null animals display impaired degradation of ubiquitinated proteins in the brain, increased ischemia/reperfusion-caused brain injury, and slower functional recovery after injury. [provided by MGI curators]
  • synonyms:
  • DA41,
  • Plic-1,
  • Dsk2,
  • RIKEN cDNA 1810030E05 gene,
  • D13Ertd372e,
  • DNA segment, Chr 13, ERATO Doi 372, expressed,
  • 1110046H03Rik,
  • expressed sequence AU019746,
  • RIKEN cDNA 1110046H03 gene,
  • XDRP1,
  • AU019746,
  • C77538,
  • ubiquilin 1,
  • MGI:1917327,
  • 1810030E05Rik,
  • MGI:2145489,
  • Ubqln1,
  • expressed sequence C77538,
  • MGI:2145351,
  • MGI:1916055,
  • MGI:1196410
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Features --> Cross References

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1 Involved In Mutations

Trail: ProteinCodingGene

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1 Transgenic Expressors

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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