| Type | MGI:General | Description | mouse embryonic fibroblasts (MEFs) fail to arrest at G1 at low ionizing radiation (IR) doses but behave normally at higher doses mutants exposed to IR radiation exhibit a shorter duration of the G2/M checkpoint in the epidermis than wild-type, with mitosis resuming by 24 hours post-IR gamma-irradiated thymic cells show a partial defect in G1/S-phase checkpoint, with a milder G1 arrest than observed in Trp53 and Atm mutants |
