| First Author | Chan CB | Year | 2011 |
| Journal | EMBO Rep | Volume | 12 |
| Issue | 8 | Pages | 847-54 |
| PubMed ID | 21720388 | Mgi Jnum | J:174775 |
| Mgi Id | MGI:5141160 | Doi | 10.1038/embor.2011.108 |
| Citation | Chan CB, et al. (2011) The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep 12(8):847-54 |
| abstractText | Dysfunction of hepatic insulin receptor tyrosine kinase (IRTK) causes the development of type 2 diabetes. However, the molecular mechanism regulating IRTK activity in the liver remains poorly understood. Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enhancer of hepatic IRTK. Liver-specific Pike-knockout (LPKO) mice display glucose intolerance with impaired hepatic insulin sensitivity. Specifically, insulin-provoked phosphoinositide 3-kinase/Akt signalling is diminished in the liver of LPKO mice, leading to the failure of insulin-suppressed gluconeogenesis and hyperglycaemia. Thus, hepatic PIKE-A has a key role in mediating insulin signal transduction and regulating glucose homeostasis in the liver. |
