| First Author | Nakayama E | Year | 1989 |
| Journal | Proc Natl Acad Sci U S A | Volume | 86 |
| Issue | 4 | Pages | 1352-6 |
| PubMed ID | 2645579 | Mgi Jnum | J:43413 |
| Mgi Id | MGI:1097611 | Doi | 10.1073/pnas.86.4.1352 |
| Citation | Nakayama E, et al. (1989) Sequence of the Lyb-2 B-cell differentiation antigen defines a gene superfamily of receptors with inverted membrane orientation. Proc Natl Acad Sci U S A 86(4):1352-6 |
| abstractText | Lyb-2 is a mouse B-cell differentiation antigen expressed on the surface of pre-B cells and B cells but not on terminally differentiated antibody-secreting plasma cells. Lyb-2 has been shown to play a role in B-cell activation and differentiation and may be a receptor for a B-cell growth factor or lymphokine. We have isolated and sequenced cDNA encoding the Lyb-2.1 allele. Lyb-2 mRNA is expressed only in B-lineage cells and is absent from antibody-secreting cell lines. The predicted protein contains 354 amino acids and is lacking an amino-terminal signal peptide. The protein is shown to be oriented with its carboxyl terminus external to the cell. Sequence comparisons demonstrate that Lyb-2 is homologous to the asialoglycoprotein receptor and to CD23, the B-cell-specific Fc receptor for IgE, both of which are oriented with their carboxyl termini external to the cell. These molecules, therefore, constitute a gene superfamily of cell surface receptors with inverted membrane orientation. |
