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Comment :

Type  MGI:General Description  on a 0.015% cholesterol diet, gallbladder cholesterol is increased 13-fold compared to wild-type, whereas phospholipid and bile acid concentrations are maintained on a 0.2% cholesterol diet, cholesterol increases in the gallbladder, but levels are 5-fold lower than wild-type molar ratios of biliary cholesterol are 14-fold lower when fed a 0.015% cholesterol diet, and 5-fold lower on a 0.2% cholesterol diet compared to wild-type mice biliary cholesterol excretion is restored by treatment with ezetimide for 4 days; bile from treated mice has a 10-fold higher cholesterol concentration compared to vehicle-treated transgenic mice, but molar ratio of biliary cholesterol in treated mutants is similar to levels in treated wild-type