| First Author | Campbell HD | Year | 2000 |
| Journal | Genomics | Volume | 68 |
| Issue | 1 | Pages | 89-92 |
| PubMed ID | 10950931 | Mgi Jnum | J:64127 |
| Mgi Id | MGI:1888775 | Doi | 10.1006/geno.2000.6259 |
| Citation | Campbell HD, et al. (2000) Human and mouse homologues of the drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins. Genomics 68(1):89-92 |
| abstractText | We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene was determined. The mouse protein is 91% identical to the human protein. Hydrophobicity analysis of the tty-related proteins indicates that they represent a new family of membrane proteins with five potential membrane-spanning regions. The yeast FTR1 and FTH1 iron transporter proteins and the mammalian neurotensin receptors 1 and 2 have a similar hydrophobicity profile, although there is no detectable sequence homology to the tty-related proteins. This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors. TTYH1 was mapped to chromosome 19q13.4 by FISH and by radiation hybrid mapping using the Stanford G3 panel. Copyright 2000 Academic Press. |
