| First Author | Hofer M | Year | 1995 |
| Journal | Folia Biol (Praha) | Volume | 41 |
| Issue | 2 | Pages | 112-7 |
| PubMed ID | 7656994 | Mgi Jnum | J:25967 |
| Mgi Id | MGI:73671 | Citation | Hofer M, et al. (1995) Enhancement by carboxymethylglucan of early cellular damage in 1 Gy-irradiated mice. Folia Biol (Praha) 41(2):112-7 |
| abstractText | Our results describe a novel carboxymethylglucan (CMG) activity, namely its radiosensitizing effect on early cellular damage in mice gamma-irradiated with a dose of 1 Gy. An increase of thymidine levels in blood plasma, determined 4 h after irradiation, was used as an indicator of the early cell death. The radiosensitizing effect was observed when administering CMG at time intervals close to irradiation time (1 h before to 1 h after irradiation). Diclofenac (an inhibitor of prostaglandin production) had no modifying effects on elevation of plasma thymidine levels induced by radiation or radiation + CMG. Pentoxifylline (an inhibitor of synthesis of tumour necrosis factor and of phosphodiesterase) administration elevated plasma thymidine to similar levels as CMG alone, combined pentoxifylline + CMG treatment had not additive effects. |
