| Primary Identifier | MGI:2447775 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 268882 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ubiquitin ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of synaptic vesicle exocytosis. Acts upstream of or within nervous system development. Located in postsynaptic density. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in nervous system. Orthologous to human FBXO45 (F-box protein 45). PHENOTYPE: Mice homozygous for a null mutation display neonatal lethality with respiratory failure, impaired motor neuron innervation and neuromuscular synapse morphology, abnormal sensory neuron projections, absence of several of the major axon tracts in the brain, and impaired neuron migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
