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Allele : Ddx4<tm1.2Embrp> DEAD box helicase 4; targeted mutation 1.2, Ramesh Pillai
Primary Identifier  MGI:5911766 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ddx4
Transmission  Germline Strain of Origin  (C57BL/6 x 129P2/OlaHsd)F1
Is Recombinase  false Is Wild Type  false
molecularNote  LoxP sites were inserted into intron 15 and 16 and glutamic acid codon 446 (GAA) in exon 16 was changed to glutamine (CAA) (p.E446Q). This mutation is expected to disrupt the protein activity. The kanamycin-neomycin resistance gene cassette that was inserted into intron 15 was removed through subsequent Flp-mediated recombination. Cre-mediated recombination removed modified exon 16.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Mvh<KI>,
  • Mvh<KI>,
  • Mvh<E446Q>,
  • Mvh<E446Q>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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