| First Author | Kooijman R | Year | 1997 |
| Journal | J Endocrinol | Volume | 155 |
| Issue | 1 | Pages | 165-70 |
| PubMed ID | 9390019 | Mgi Jnum | J:43645 |
| Mgi Id | MGI:1098177 | Doi | 10.1677/joe.0.1550165 |
| Citation | Kooijman R, et al. (1997) T and B cell development in pituitary deficient insulin-like growth factor-II transgenic dwarf mice. J Endocrinol 155(1):165-70 |
| abstractText | Treatment of mice with IGF-I stimulates T and B cell development. We showed that overexpression of IGF-II in transgenic FVB/N mice only stimulated T cell development. In the present study, we further addressed the in vivo effects of IGF-II in the absence of IGF-I to get more insight into the potential abilities of IGF-II to influence T and B cell development. To this end, we studied lymphocyte development in IGF-II transgenic Snell dwarf mice that are prolactin, GH and thyroid-stimulating hormone deficient and as a consequence show low serum IGF-I levels. We showed that T cell development was stimulated to the same extent as in IGF-II transgenic FVB/N mice. Furthermore, IGF-II increased the number of nucleated bone marrow cells and the number of immature B cells without having an effect on the number of mature B cells in spleen and bone marrow. Our data show that IGF-II has preferential effects on T cell development compared with B development, and that these preferential effects also occur in the absence of measurable IGF-I levels. |
