| First Author | Tu Z | Year | 2001 |
| Journal | Blood | Volume | 98 |
| Issue | 7 | Pages | 2028-38 |
| PubMed ID | 11567986 | Mgi Jnum | J:72115 |
| Mgi Id | MGI:2151745 | Doi | 10.1182/blood.v98.7.2028 |
| Citation | Tu Z, et al. (2001) Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Blood 98(7):2028-38 |
| abstractText | SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP isoform expressed in differentiated hematopoietic cells. s-SHIP is also expressed in primitive hematopoietic stem cells, but not in lineage-committed hematopoietic cells. In embryonic stem cells, s-SHIP partners with the adapter protein Grb2 without tyrosine phosphorylation and is present constitutively at the cell membrane. It is postulated that s-SHIP modulates the activation threshold of primitive stem cell populations. (Blood. 2001;98:2028-2038) |
