First Author | Wang D | Year | 2012 |
Journal | Nat Immunol | Volume | 13 |
Issue | 6 | Pages | 560-8 |
PubMed ID | 22561606 | Mgi Jnum | J:186446 |
Mgi Id | MGI:5432321 | Doi | 10.1038/ni.2301 |
Citation | Wang D, et al. (2012) Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol 13(6):560-8 |
abstractText | Signaling via the T cell antigen receptor (TCR) during the CD4(+)CD8(+) double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell-expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1(-/-) mice had fewer mature thymic CD4(+) and CD8(+) T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-gamma1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk-AP-1 and Ca(2+)-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. |