| First Author | Jarjour AA | Year | 2008 |
| Journal | J Neurosci | Volume | 28 |
| Issue | 43 | Pages | 11003-14 |
| PubMed ID | 18945908 | Mgi Jnum | J:143795 |
| Mgi Id | MGI:3829100 | Doi | 10.1523/JNEUROSCI.3285-08.2008 |
| Citation | Jarjour AA, et al. (2008) Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. J Neurosci 28(43):11003-14 |
| abstractText | Paranodal axoglial junctions are essential for the segregation of myelinated axons into distinct domains and efficient conduction of action potentials. Here, we show that netrin-1 and deleted in colorectal cancer (DCC) are enriched at the paranode in CNS myelin. We then address whether netrin-1 signaling influences paranodal adhesion between oligodendrocytes and axons. In the absence of netrin-1 or DCC function, oligodendroglial paranodes initially develop and mature normally but later become disorganized. Lack of DCC or netrin-1 resulted in detachment of paranodal loops from the axonal surface and the disappearance of transverse bands. Furthermore, the domain organization of myelin is compromised in the absence of netrin-1 signaling: K+ channels inappropriately invade the paranodal region, and the normally restricted paranodal distribution of Caspr expands longitudinally along the axon. Our findings identify an essential role for netrin-1 and DCC regulating the maintenance of axoglial junctions. |
