| First Author | Wendling F | Year | 1994 |
| Journal | Nature | Volume | 369 |
| Issue | 6481 | Pages | 571-4 |
| PubMed ID | 8202160 | Mgi Jnum | J:18897 |
| Mgi Id | MGI:67117 | Doi | 10.1038/369571a0 |
| Citation | Wendling F, et al. (1994) cMpl ligand is a humoral regulator of megakaryocytopoiesis [see comments]. Nature 369(6481):571-4 |
| abstractText | Megakaryocytopoiesis is the cellular developmental process that leads to platelet production. At least two humoral growth factors may be necessary for megakaryocyte proliferation and maturation. One is a megakaryocyte-colony stimulating factor (MK-CSF) which induces the proliferation and differentiation of megakaryocyte progenitors, and the second, thrombopoietin, is a megakaryocyte maturation factor. Neither of these factors has been fully characterized. The proto-oncogene c-mpl, an orphan member of the haematopoietin receptor family, is specifically involved in megakaryocyte regulation. Here we present evidence that the c-mpl-encoded receptor binds a ligand (c-Mpl ligand) which is a humoral factor implicated in platelet homeostasis. Our results suggest that c-Mpl ligand, thrombopoietin and MK-CSF might be the same molecule. |
