| First Author | Murakami M | Year | 2006 |
| Journal | J Mol Cell Cardiol | Volume | 41 |
| Issue | 1 | Pages | 115-25 |
| PubMed ID | 16787652 | Mgi Jnum | J:110984 |
| Mgi Id | MGI:3652477 | Doi | 10.1016/j.yjmcc.2006.05.002 |
| Citation | Murakami M, et al. (2006) Identification of a cardiac isoform of the murine calcium channel alpha1C (Ca(v)1.2-a) subunit and its preferential binding with the beta2 subunit. J Mol Cell Cardiol 41(1):115-25 |
| abstractText | We describe a cardiac muscle isoform of the voltage-dependent calcium channel alpha1 subunit, which corresponds to the rabbit ortholog of alpha1C-a (Ca(v)1.2a). We also cloned smooth muscle isoforms alpha1C-b (Ca(v)1.2b) and alpha1C-d (Ca(v)1.2d). Differences among these three isoforms lie within the N-terminal region (exon 1A or 1B), the sixth transmembrane segment of domain I (exon 8A or 8B), and the use of exon 10, which forms the intracellular loop between transmembrane domains I and II. Two-hybrid analysis revealed interactions among the three alpha1 isoforms and beta subunits. In vitro overlay and immunoprecipitation analyses revealed preferential binding between alpha1C-a and beta2, which is also expressed at a high level in the heart. |
