| Primary Identifier | MGI:1338889 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18140 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including hemi-methylated DNA-binding activity; histone H3 ubiquitin ligase activity; and identical protein binding activity. Involved in negative regulation of gene expression via CpG island methylation and negative regulation of transcription by RNA polymerase II. Located in nuclear matrix and replication fork. Part of heterochromatin. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). PHENOTYPE: Mice homozygous for disruption of this marker die early in gestation showing growth retardation and various malformations. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
