| First Author | Dickens M | Year | 1997 |
| Journal | Science | Volume | 277 |
| Issue | 5326 | Pages | 693-6 |
| PubMed ID | 9235893 | Mgi Jnum | J:50502 |
| Mgi Id | MGI:1306759 | Doi | 10.1126/science.277.5326.693 |
| Citation | Dickens M, et al. (1997) A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277(5326):693-6 |
| abstractText | The c-Jun amino-terminal kinase (JNK) is a member of the stress-activated group of mitogen-activated protein (MAP) kinases that are implicated in the control of cell growth. A murine cyto-plasmic protein that binds specifically to JNK [the JNK interacting protein-1 (JIP-1)] was character-ized and cloned. JIP-1 caused cytoplasmic retention of JNK and inhibition of JNK-regulated gene expression. In addition, JIP-1 suppressed the effects of the JNK signaling pathway on cellular proliferation, including transformation by the Bcr-Abl oncogene. This analysis identifies JIP-1 as a specific inhibitor of the JNK signal transduction pathway and establishes protein targeting as a mechanism that regulates signaling by stress-activated MAP kinases. |
