| First Author | Szabo SJ | Year | 2002 |
| Journal | Science | Volume | 295 |
| Issue | 5553 | Pages | 338-42 |
| PubMed ID | 11786644 | Mgi Jnum | J:73833 |
| Mgi Id | MGI:2156935 | Doi | 10.1126/science.1065543 |
| Citation | Szabo SJ, et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338-42 |
| abstractText | T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage. |
