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Publication : A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2.

First Author  Mack HG Year  1997
Journal  Gene Volume  185
Issue  1 Pages  11-7
PubMed ID  9034307 Mgi Jnum  J:38274
Mgi Id  MGI:85651 Doi  10.1016/s0378-1119(96)00607-5
Citation  Mack HG, et al. (1997) A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2. Gene 185(1):11-7
abstractText  Whilst searching for a mammalian homologue of the Drosophila glass gene we cloned a mouse cDNA whose deduced sequence encodes a 614 amino acid (aa) protein with ten Cys2-His2 (C2H2) zinc finger (Zf) motifs. Zfp64 is expressed in all developing and mature mouse tissues examined, except the mouse erythroleukemia (MEL) cell line. Zfp64 maps to the distal region of mouse chromosome 2 close to lens opacity 4 (Lop4), a semidominant cataract mutation. Sequence analysis shows that Zfp64 has multiple potential phosphorylation sites for casein kinase II (CK II), protein kinase C (PKC), tyrosine kinase (TK) and c- AMP- and c-GMP-dependent protein kinase (cA/GMPDPK).
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