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Comment :

Type  subunit Description  Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity). Complex I associates with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (PubMed:27799543). In astrocytes, less complex I is assembled into supercomplexes as compared to neurons (PubMed:27799543). Interacts with MDM2 (By similarity). Interacts with AKAP1 (PubMed:32072193).