mice show susceptibility to intranasal infection with the SARS-CoV-2 stock virus HB-01 (BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119), with mice showing weight loss of up to 8% at 5 days post infection (dpi) that is not seen in wild-type controls and viral loads detected in lungs with highest virus titers detected at 3 dpi in the lungs specific IgG antibodies against S protein of SARS-CoV-2 are detected in the sera of infected mice at 21 dpi viral antigens are detected within alveolar macrophages, alveolar epithelia, and degenerative/desquamated bronchial epithelial cells of SARS-CoV-2-infected mice small amounts of viral antigens are detected in respiratory epithelial cells within non-lesional areas of the lungs infectious virus is isolated from the lungs at 1, 3, and 5 dpi, with highest viral titers at 3 dpi
