| First Author | MacDonald AS | Year | 1999 |
| Journal | Pathobiology | Volume | 67 |
| Issue | 5-6 | Pages | 265-8 |
| PubMed ID | 10725799 | Mgi Jnum | J:61096 |
| Mgi Id | MGI:1354442 | Doi | 10.1159/000028107 |
| Citation | MacDonald AS, et al. (1999) Suppressive antigen-presenting cells in Helminth infection. Pathobiology 67(5-6):265-8 |
| abstractText | Infection with filarial nematodes is commonly associated with a failure of T cells to proliferate in response to parasite antigen. We have investigated the possibility that antigen-presenting cells recruited during filarial infection are responsible for impairment of T cell function. We have found that the human filarial parasite Brugia malayi, when implanted into the peritoneal cavity of mice, recruits a population of adherent cells that actively block the proliferation of T cells. Phenotypic analysis of the recruited cells reveals large numbers of both macrophages and eosinophils and cell sorting experiments demonstrate that these antiproliferative cells are Mac-1-positive. Studies in gene-deficient mice have demonstrated that proliferative suppression is dependent on the in vivo production of IL-4 but not IL-5 or IL-10, while suppression in vitro is not mediated by any known antiproliferative factor. Our results suggest that helminth infection can lead to the development and/or recruitment of an IL-4-dependent macrophage population that mediates suppression via a novel mechanism. Copyright 2000 S. Karger AG, Basel. |
