| Primary Identifier | MGI:1916885 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 69635 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ATP binding activity; calmodulin binding activity; and protein kinase activity. Involved in cellular response to type II interferon; intracellular signal transduction; and negative regulation of apoptotic process. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1). PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
