| First Author | Ma W | Year | 2013 |
| Journal | J Biol Chem | Volume | 288 |
| Issue | 41 | Pages | 29369-81 |
| PubMed ID | 23960076 | Mgi Jnum | J:207248 |
| Mgi Id | MGI:5554980 | Doi | 10.1074/jbc.M113.454066 |
| Citation | Ma W, et al. (2013) An androgen receptor-microrna-29a regulatory circuitry in mouse epididymis. J Biol Chem 288(41):29369-81 |
| abstractText | MicroRNAs are involved in a number of cellular processes; thus, their deregulation is usually apt to the occurrence of diverse diseases. Previous studies indicate that abnormally up-regulated miR-29a is associated with several diseases, such as human acute myeloid leukemia and diabetes; therefore, the proper level of miR-29a is critical for homeostasis. Herein, we observed that miR-29a was repressed by androgen/androgen receptor signaling in mouse epididymis by targeting a conserved androgen response element located 8 kb upstream of miR-29b1a loci. It is well known that multiple regulatory programs often form a complicated network. Here, we found that miR-29a reversibly suppressed androgen receptor and its target genes by targeting IGF1 and p53 pathways. miR-29b1a-overexpressing transgenic mice displayed epididymis hypoplasia partially similar to the phenotype of those mice with an impaired androgen-androgen receptor signal system. Taken together, the results demonstrated that there is a regulatory circuitry between the androgen signaling pathway and miR-29a in mouse epididymis that may be vital for epididymal development and functions. |
