| First Author | Deegan S | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 451 |
| Issue | 3 | Pages | 367-73 |
| PubMed ID | 25086361 | Mgi Jnum | J:220121 |
| Mgi Id | MGI:5632258 | Doi | 10.1016/j.bbrc.2014.07.111 |
| Citation | Deegan S, et al. (2014) ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. Biochem Biophys Res Commun 451(3):367-73 |
| abstractText | Cells respond to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR), autophagy and cell death. In this study we utilized casp9(+/+) and casp9(-/-) MEFs to determine the effect of inhibition of mitochondrial apoptosis pathway on ER stress-induced-cell death, UPR and autophagy. We observed prolonged activation of UPR and autophagy in casp9(-/-) cells as compared with casp9(+/+) MEFs, which displayed transient activation of both pathways. Furthermore we showed that while casp9(-/-) MEFs were resistant to ER stress, prolonged exposure led to the activation of a non-canonical, caspase-mediated mode of cell death. |
