| First Author | Sano S | Year | 1997 |
| Journal | FEBS Lett | Volume | 411 |
| Issue | 2-3 | Pages | 327-34 |
| PubMed ID | 9271230 | Mgi Jnum | J:42131 |
| Mgi Id | MGI:1095217 | Doi | 10.1016/s0014-5793(97)00724-2 |
| Citation | Sano S, et al. (1997) BIT, an immune antigen receptor-like molecule in the brain. FEBS Lett 411(2-3):327-34 |
| abstractText | We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine-based activation motifs (TAM) that are variants of the antigen receptor signaling motifs. The overall structure is similar to those of immune antigen receptors. This molecule, BIT (brain immunoglobulin-like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro. Cerebral cortical neurons could extend their neurites on BIT-coated substrate and anti-BIT monoclonal antibody specifically inhibited the effect. These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor-like molecule of the brain, functions as a membrane signaling molecule that may participate in cell-cell interaction. |
