| First Author | Calamito M | Year | 2010 |
| Journal | Blood | Volume | 115 |
| Issue | 20 | Pages | 4043-50 |
| PubMed ID | 20042722 | Mgi Jnum | J:160279 |
| Mgi Id | MGI:4453957 | Doi | 10.1182/blood-2009-09-241638 |
| Citation | Calamito M, et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115(20):4043-50 |
| abstractText | Although the 3 isoforms of Akt regulate cell growth, proliferation, and survival in a wide variety of cell types, their role in B-cell development is unknown. We assessed B-cell maturation in the bone marrow (BM) and periphery in chimeras established with fetal liver progenitors lacking Akt1 and/or Akt2. We found that the generation of marginal zone (MZ) and B1 B cells, 2 key sources of antibacterial antibodies, was highly dependent on the combined expression of Akt1 and Akt2. In contrast, Akt1/2 deficiency did not negatively affect the generation of transitional or mature follicular B cells in the periphery or their precursors in the BM. However, Akt1/2-deficient follicular B cells exhibited a profound survival defect when forced to compete against wild-type B cells in vivo. Altogether, these studies show that Akt signaling plays a key role in peripheral B-cell maturation and survival. |
