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Allele : Adar<em1Crwy> adenosine deaminase, RNA-specific; endonuclease-mediated mutation 1, Carl R Walkley

Primary Identifier  MGI:7514376 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Adar
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  Proline codon 195 (CCT) in exon 2 was changed to alanine (GCT) (p.P195A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.P193A mutation associated with Aicardi–Goutieres Syndrome (AGS).
  • mutations:
  • Single point mutation
  • synonyms:
  • Adar1<P195A>,
  • Adar1<P195A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele