Primary Identifier | MGI:7514376 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Adar |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Proline codon 195 (CCT) in exon 2 was changed to alanine (GCT) (p.P195A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. This mutation is the equivalent of the human p.P193A mutation associated with AicardiâGoutieres Syndrome (AGS). |