| First Author | Wilcox SA | Year | 1996 |
| Journal | Genomics | Volume | 35 |
| Issue | 1 | Pages | 66-70 |
| PubMed ID | 8661105 | Mgi Jnum | J:35288 |
| Mgi Id | MGI:82738 | Doi | 10.1006/geno.1996.0323 |
| Citation | Wilcox SA, et al. (1996) Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement. Genomics 35(1):66-70 |
| abstractText | Previous comparisons of gene location in the three major groups of mammals (eutherians, marsupials, and monotremes) have suggested that the long arm of the human X represents the ancestral mammalian X chromosome, whereas the short arm represents an autosomal region(s) recently added to the eutherian X chromosome. To identify the fusion point of this ancient X-autosome rearrangement, we have mapped four genes, three of which map near the centromere of the human Xp, in marsupials and in a monotreme. We found that ARAF1, ALAS2, and GATA1 are located on the X chromosome in marsupials, and ALAS2 and GATA1 are also located on the X in the platypus. This implies that the proximal short arm of the human X chromosome, including the centromere, was part of the ancestral mammalian X chromosome. The fusion point between the conserved region and the recently added regions therefore maps to human Xp11.23, although gene order on the human X indicates that there has been some rearrangement of this region. |
