| First Author | Takahashi T | Year | 1999 |
| Journal | Cell | Volume | 99 |
| Issue | 1 | Pages | 59-69 |
| PubMed ID | 10520994 | Mgi Jnum | J:57968 |
| Mgi Id | MGI:1346254 | Doi | 10.1016/s0092-8674(00)80062-8 |
| Citation | Takahashi T, et al. (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99(1):59-69 |
| abstractText | Class 1 and 3 semaphorins repulse axons but bind to different cell surface proteins. We find that the two known semaphorin-binding proteins, plexin 1 (Plex 1) and neuropilin-1 (NP-1), form a stable complex. Plex 1 alone does not bind semaphorin-3A (Sema3A), but the NP-1/Plex 1 complex has a higher affinity for Sema3A than does NP-1 alone. While Sema3A binding to NP-1 does not alter nonneuronal cell morphology, Sema3A interaction with NP-1/Plex 1 complexes induces adherent cells to round up. Expression of a dominant-negative Plex 1 in sensory neurons blocks Sema3A-induced growth cone collapse. Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes. |
