| First Author | Hu MC | Year | 1998 |
| Journal | J Biol Chem | Volume | 273 |
| Issue | 50 | Pages | 33561-5 |
| PubMed ID | 9837938 | Mgi Jnum | J:64812 |
| Mgi Id | MGI:1890006 | Doi | 10.1074/jbc.273.50.33561 |
| Citation | Hu MC, et al. (1998) Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem 273(50):33561-5 |
| abstractText | Nuclear factor kappaB (NF-kappaB) and the Rel family of proteins are pleiotropic transcription factors that play central roles in the immune and inflammatory responses, as well as apoptosis. Here, we identified a serine/threonine protein phosphatase X (PPX; also called protein phosphatase 4 (PP4)) that specifically associated with c-Rel, NF-kappaB p50, and RelA. The amino acid sequences of human and mouse PPX are 100% identical, and the PPX gene was mapped to human chromosome 16 p11.2. Overexpression of PPX, but not catalytically inactive PPX mutants, stimulated the DNA-binding activity of c-Rel and activated NF-kappaB-mediated transcription. These results suggest that PPX is a novel activator of c-Rel/NF-kappaB. |
